TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
نویسندگان
چکیده
منابع مشابه
The vertebrate inner ear mediates hearing and balance through a complex arrangement of mechanosensory hair cells, nonsensory
INTRODUCTION The vertebrate inner ear mediates hearing and balance through a complex arrangement of mechanosensory hair cells, nonsensory supporting cells and sensory neurons. All of these cell types derive from the otic placode, a transient ectodermal thickening adjacent to the developing hindbrain (Barald and Kelley, 2004; Fritzsch et al., 2006). Otic placode formation is a multistep process ...
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Sensory transduction in auditory and vestibular hair cells requires expression of transmembrane channel-like (Tmc) 1 and 2 genes, but the function of these genes is unknown. To investigate the hypothesis that TMC1 and TMC2 proteins are components of the mechanosensitive ion channels that convert mechanical information into electrical signals, we recorded whole-cell and single-channel currents f...
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Inner ear hair cells are the sensory receptors that detect and convert sound vibrations and head movements into neural signals. However, in humans, these cells are unable to regenerate if they are damaged or lost. Over thepast decade,there has been an exponential increase in interest and progress in understanding of the development of the inner ear and of hair cells, aiming to gain insights int...
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ژورنال
عنوان ژورنال: Neuron
سال: 2018
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2018.07.033